Prijepolje Museum was founded in 1990. It has a complex museum collection, consisting of the Museum of the pioneers and youth of Yugoslavia at the Jabuka, near Prijepolje, at Jusufagic House and House of Veseličića.

He received the status of a regional museum in 1995.

For twenty years of work there have been organized important national projects, reconstruction of ruined medieval monastery, scientific research and reconnaissance, scientific conferences, lectures, museum exhibitions at home and abroad, the protection of Islamic monuments and great art projects. The crown represents the success of the reconstruction of the building of the Museum by European standards, and recognition of the NIP to the reconstruction project declared a project of priority in the culture of Serbia.

One of the few museums in Serbia, which has established a very successful decade-long cooperation with SANU, Philosophy and the Faculty of Philology in Belgrade, whose eminent scholars participate in our research and other projects.

After the realized and highly ranked project and references the Museum in Prijepolje falls into one of the leading museum institutions in Serbia, and for this reason the then minister of culture of the Republic of Serbia, the Museum in central entrusted the organization of the "European Heritage Days" in 2009.

Museum in Prijepolje with his work drew the attention of not only professional, scientific and other public, resulting in the electronic and print media in significant emissions and descriptions in the press informing the public about the results of this by the number of employees of a small but very successful team.

Thanks to the realized copyright, a national project funded by the Ministry of culture of the Republic of Serbia Museum in Prijepolje was in Portugal on 19th May 2012. by the European Museum Forum, under the auspices of the Council of Europe, in competition with 59 European museums received the prestigious Special Award for authoring projects implemented to protect cultural heritage and achieved an overall social role in the complicated and burdened with a multi-ethnic area in which it is operating, which is managed to establish cooperation with national museums in the region, paving the way for cooperation in spite of unfavorable political situation, which has made it difficult. The award is the first such recognition granted not only Serbia, but also the wider part of the Balkans. This is a great recognition, it is important not only for the Museum in but for the Serbian museology in general.